We study how cellular identity is established during development and how it is maintained in the adult organism, and how it balances the need to ensure stability and allow plasticity when necessary. We use organoid based human ex vivo models as well as in vivo mouse models to study lung tissue homeostasis, regeneration and tumorigenesis.
Many human diseases are a result of either a deficit or surfeit in the quantity or functionality of particular cell types. Although the principles of cell fate specification during embryogenesis are rather well documented, it is unclear what mechanisms are used to maintain cell identity andappropriate cell numbers in adult tissues. While the cell autonomous… Continue reading About us