Understanding the genetic and epigenetic basis of cell identity and plasticity in regeneration and tumorigenesis
Check out our contributions to the latest COVID-19 research!
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors…Read more…..
Here, we leverage human and non-human primate (NHP) single-cell RNA-sequencing (scRNA-seq) datasets to uncover the cell subsets that may serve as cellular targets of SARS-CoV-2…Read more……
Here, we assess the cell type-specific RNA expression of ACE2, TMPRSS2, and CTSL through an integrated analysis of 107 single-cell and single-nucleus RNA-Seq studies, including 22 lung and airways datasets (16 unpublished), and 85 datasets from other diverse organs…Read more…..
Brigid Hogan and Purushothama Rao Tata illustrate the cellular architecture of the respiratory system and highlight key cell types residing in different regions, including their markers, functions, lineage relationships and pathological relevance, as well as approaches to culturing and studying them in vitro.
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