Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2 mediated interferon responses and pneumocyte dysfunction
Tata Lab contributing authors: Sontake V*, Tata A*, Katsura H*, Kobayashi Y*, Konkimalla A, Tata PR. (*Equal contribution). Published in Cell Stem Cell. Oct 2020
Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis
Tata Lab contributing authors: Kobayashi Y, Tata A, Konkimalla A, Katsura H, Lee R & Tata PR. Published in Nature Cell Biology. Aug 2020
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract
Tata Lab contributing authors: Tata PR. & Sontake V. Published in Cell. May 2020
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
Tata Lab contributing authors: Kobayashi Y. and Tata PR. Preprint in bioRxiv. April 2020
SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Enriched in Specific Cell Subsets Across Tissues
Tata Lab contributing authors: Tata PR. Published in Cell. April 2020
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
Tata Lab contributing authors: Tata PR. Nature Medicine. April 2020
Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice
Tata Lab contributing authors: Kobayashi Y, Tata PR. Published in eLife. Dec 2019
Persistence of a novel regeneration-associated transitional cell state in pulmonary fibrosis
Tata Lab contributing authors: Kobayashi Y*, Tata A*, Konkimalla A, Katsura H, Lee RF, Tata PR. (*Equal contribution). Published in bioRxiv. Nov 2019)
Cellular organization and biology of the respiratory system
Tata Lab contributing authors: Tata, P.R. Published in Nat Cell Biol. July 2019
IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration
Tata Lab contributing authors: Katsura H, Kobayashi Y, Tata PR§ (§ Corresponding author). Published in Stem Cell Rep. Apr 2019
ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia
Tata Lab contributing authors: Tata PR. Published in Proc Natl Acad Sci USA. Jan 2019
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
Tata Lab contributing authors: Tata PR. Published in Nature. Aug 2018
Pulmonary Neuroendocrine Cells: Sensors and Sentinels of the Lung
Tata Lab contributing authors: Kobayashi, Y., and Tata, P.R. Published in Developmental Cell. May 2018
Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury
Tata Lab contributing authors: Tata A, Kobayashi Y, Desai A, Tata PR§ (§ Corresponding author). Published in Cell Stem Cell. May 2018
Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity
Tata Lab contributing authors: Tata PR§, Tata A, Konkimalla A (§Corresponding author). Published in Developmental Cell. Mar 2018
A Conserved Distal Lung Regenerative Pathway in Acute Lung Injury
Tata Lab contributing authors: Tata PR. Published in Am J Pathol. Feb 2018
Plasticity in Olfactory Epithelium: Is It a Sniffer or Shape Shifter?
Tata Lab contributing authors: Konkimalla A, Tata PR. Published in Cell Stem Cell. Dec 2017
Delayed Alveolar Epithelization: A Distinct Pathology in Diffuse Acute Lung Injury
Tata Lab contributing authors: Tata PR. Published in Am J Respir Crit Care Med. Jul 2017
Plasticity in the lung: making and breaking cell identity
Tata Lab contributing authors: Tata PR. Published in Development. Mar 2017
The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis
Tata Lab contributing authors: Tata PR. Published in Developmental Biology. Feb 2017
ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis
Tata Lab contributing authors: Tata PR. Published in Cancer Cell. Jan 2017
Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny
Tata Lab contributing authors: Tata PR. Published in Cell Stem Cell. Dec 2016
Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
Tata Lab contributing authors: Tata PR. Published in Cell Stem Cell. Aug 2016
Cellular plasticity: 1712 to the present day
Tata Lab contributing authors: Tata PR. Published in Curr Opin Cell Biol. Dec 2016
Parent stem cells can serve as niches for their daughter cells
Tata Lab contributing authors: Tata PR. Published in Nature. July 2015
Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations
Tata Lab contributing authors: Tata PR. Published in Cell Stem Cell. Feb 2015
Dedifferentiation of committed epithelial cells into stem cells in vivo
Tata Lab contributing authors: Tata PR. Published in Nature. Nov 2013
Airway Specific Inducible Transgene Expression Using Aerosolized Doxycycline
Tata Lab contributing authors: Tata PR. Published in Am J Respir Cell Mol Biol. Jul 2013
Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target
Tata Lab contributing authors: Tata PR. Published in Genes Dev. Jan 2013
TBX3 Directs Cell-Fate Decision toward Mesendoderm
Tata Lab contributing authors: Tata PR. Published in Stem Cell Reports. May 2014
Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC
Tata Lab contributing authors: Tata PR. Published in Nucleic Acids Res. May 2011
An updated overview on Wnt signaling pathways: a prelude for more
Tata Lab contributing authors: Tata PR. Published in Circ Res. Jun 2010
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Laboratory of Stem Cells and Tissue Regeneration 